This demonstrates the existence of “cue cells” in addition to better characterized “place cells” in the DG. Cue cell responses are stable, stimulus-specific, and accompanied by inhibition of nearby neurons. Using two-photon calcium imaging in mice running on a treadmill along with online cue manipulation, we identify robust sensory cue responses in DG granule cells. The dentate gyrus (DG) is the first stage of the hippocampal circuit where self-motion (“where”) and sensory cue information (“what”) are integrated, but it remains unknown how DG neurons encode this information during cognitive map formation. During exploration, animals form an internal map of an environment by combining information about landmarks and the animal’s movement, a process that depends on the hippocampus.
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